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Molecular epidemiology of lymphomas

The objective of the present project is to identify individual conditions and external factors associated with lymphoma aetiology, the response to therapy and survival, as possible targets for preventive action and possible drivers of new individualized therapeutic strategies. This objective will be pursued by matching genomic data with occupational and environmental exposures, individual characteristics and habits, lifestyle factors, and clinical history, using the case control epidemiological study design. After signing the informed consent form, cases and controls will donate a blood sample and respond to a detailed questionnaire on the exposures of interest. Here are the main features of the present project: 1)Genome Wide Scan of patients and controls DNA, which aims to evaluate several million SNPs, some functionally known, and other in strict linkage disequilibrium with genes in loci encoding for known proteins, 2)Detailed assessment of occupational and environmental exposure 3) Analysis of response to therapy and survival of lymphoma patients in relation to their genetic features, by identifying esponders to specific chemotherapeutic agents based upon their polymorphisms of genes implicated in xenobiotic metabolism, DNA repair, release of inflammatory cytokines, as well as other yet to be identified. In this project, the student will develop skills in various techniques of molecular biology, immunohistochemistry and histology.

Interaction between polymorphisms of genes involved in the inflammatory response and metabolism of xenobiotics and occupational, environmental exposures in lymphomas.
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